PPAR Gamma Agonists and Autism

One of my favorite bloggers (Peter Lloyd-Thomas) has been blogging about PPAR-Gamma Agonists and autism recently here http://epiphanyasd.blogspot.com/2015/05/tangeretin-vs-ibuprofen-as-ppar.html.

Among Peter’s observations:

1)  Actos improves behavior in autism, and Actos is a PPAR-gamma agonist. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781426/

2) PPAR-gamma agonists have antiepileptic properties in mice.  http://grantome.com/grant/NIH/R01-NS085389-01A1#panel-abstract-body

3) Peter’s son who has autism is doing better on PPAR-gamma agonists and no longer needs ibuprofen.

Some additional observations:

4)  Cntnap2 gene defect ameliorated with biochanin A in Zebrafish. https://imfar.confex.com/imfar/2015/webprogram/Paper20670.html  Biochanin A is a PPAR-gamma agonist.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212005/

5) Luteolin formulations have shown efficacy in autism in some open label trials: http://europepmc.org/abstract/med/22697063, http://www.clinicaltherapeutics.com/article/S0149-2918(13)00178-1/abstract  Luteolin is a partial PPAR-gamma agonist.  http://www.ncbi.nlm.nih.gov/pubmed/22391103.

6) IGF-1 seems to show some efficacy in Phellan McDermid syndrome: http://www.molecularautism.com/content/5/1/54.  An herb that upregulates IGF-1 also upregulates PPAR-gamma.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117754/  Is IGF-1 also a PPAR-gamma agonist?


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